Ciliated muconodular papillary tumors of the lung with KRAS/BRAF/AKT1 mutation.
Diagn Pathol
; 12(1): 62, 2017 Aug 22.
Article
en En
| MEDLINE
| ID: mdl-28830562
ABSTRACT
BACKGROUND:
Ciliated muconodular papillary tumors (CMPTs) are newly recognized rare peripheral lung nodules that are histologically characterized by ciliated columnar, goblet, and basal cells. Although recent studies have shown that CMPTs constitute a neoplastic disease, the complete histogenesis of CMPTs is not fully understood and molecular data are limited.METHODS:
We reviewed four cases of CMPT and performed immunohistochemical and genomic analyses to establish CMPT profiles.RESULTS:
All cases were positive for hepatocyte nuclear factor-4α and mucin 5B and negative for programmed death ligand 1 expression, as determined by immunohistochemistry. The genetic analysis revealed three pathogenic mutations (BRAF V600E, AKT1 E17K, and KRAS G12D), with the KRAS mutation reported here for the first time.CONCLUSION:
Histological and genetic profiles indicate that CMPTs are likely neoplastic and exhibit features similar to mucinous adenocarcinoma. This suggests that some CMPTs may be a precursor lesion of mucinous adenocarcinoma.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Proto-Oncogénicas p21(ras)
/
Proteínas Proto-Oncogénicas B-raf
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Proteínas Proto-Oncogénicas c-akt
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Neoplasias Pulmonares
Límite:
Aged
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Diagn Pathol
Asunto de la revista:
PATOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Japón