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Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery.
Tamayol, Ali; Hassani Najafabadi, Alireza; Mostafalu, Pooria; Yetisen, Ali K; Commotto, Mattia; Aldhahri, Musab; Abdel-Wahab, Mohamed Shaaban; Najafabadi, Zeynab Izadi; Latifi, Shahrzad; Akbari, Mohsen; Annabi, Nasim; Yun, Seok Hyun; Memic, Adnan; Dokmeci, Mehmet R; Khademhosseini, Ali.
Afiliación
  • Tamayol A; Biomaterials Innovation Research Center (BIRC), Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.
  • Hassani Najafabadi A; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Mostafalu P; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.
  • Yetisen AK; Biomaterials Innovation Research Center (BIRC), Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.
  • Commotto M; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Aldhahri M; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, 48109, USA.
  • Abdel-Wahab MS; Biomaterials Innovation Research Center (BIRC), Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.
  • Najafabadi ZI; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Latifi S; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.
  • Akbari M; Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Cambridge, MA, 02139, USA.
  • Annabi N; Biomaterials Innovation Research Center (BIRC), Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.
  • Yun SH; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Memic A; Center of Nanotechnology, King Abdulaziz University, Jeddah, 21569, Saudi Arabia.
  • Dokmeci MR; Department of Biochemistry, King Abdulaziz University, Jeddah, 21569, Saudi Arabia.
  • Khademhosseini A; Center of Nanotechnology, King Abdulaziz University, Jeddah, 21569, Saudi Arabia.
Sci Rep ; 7(1): 9220, 2017 08 23.
Article en En | MEDLINE | ID: mdl-28835675
ABSTRACT
Delivery of drugs with controlled temporal profiles is essential for wound treatment and regenerative medicine applications. For example, bacterial infection is a key challenge in the treatment of chronic and deep wounds. Current treatment strategies are based on systemic administration of high doses of antibiotics, which result in side effects and drug resistance. On-demand delivery of drugs with controlled temporal profile is highly desirable. Here, we have developed thermally controllable, antibiotic-releasing nanofibrous sheets. Poly(glycerol sebacate)- poly(caprolactone) (PGS-PCL) blends were electrospun to form elastic polymeric sheets with fiber diameters ranging from 350 to 1100 nm and substrates with a tensile modulus of approximately 4-8 MPa. A bioresorbable metallic heater was patterned directly on the nanofibrous substrate for applying thermal stimulation to release antibiotics on-demand. In vitro studies confirmed the platform's biocompatibility and biodegradability. The released antibiotics were potent against tested bacterial strains. These results may pave the path toward developing electronically controllable wound dressings that can deliver drugs with desired temporal patterns.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Sistemas de Liberación de Medicamentos / Elasticidad / Nanofibras Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Sistemas de Liberación de Medicamentos / Elasticidad / Nanofibras Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos