Toward understanding of the mechanisms of Mediator function in vivo: Focus on the preinitiation complex assembly.
Transcription
; 8(5): 328-342, 2017.
Article
en En
| MEDLINE
| ID: mdl-28841352
ABSTRACT
Mediator is a multisubunit complex conserved in eukaryotes that plays an essential coregulator role in RNA polymerase (Pol) II transcription. Despite intensive studies of the Mediator complex, the molecular mechanisms of its function in vivo remain to be fully defined. In this review, we will discuss the different aspects of Mediator function starting with its interactions with specific transcription factors, its recruitment to chromatin and how, as a coregulator, it contributes to the assembly of transcription machinery components within the preinitiation complex (PIC) in vivo and beyond the PIC formation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Complejo Mediador
/
Iniciación de la Transcripción Genética
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Transcription
Año:
2017
Tipo del documento:
Article
País de afiliación:
Francia