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GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.
Mullican, Shannon E; Lin-Schmidt, Xiefan; Chin, Chen-Ni; Chavez, Jose A; Furman, Jennifer L; Armstrong, Anthony A; Beck, Stephen C; South, Victoria J; Dinh, Thai Q; Cash-Mason, Tanesha D; Cavanaugh, Cassandre R; Nelson, Serena; Huang, Chichi; Hunter, Michael J; Rangwala, Shamina M.
Afiliación
  • Mullican SE; Cardiovascular and Metabolism Therapeutic Area, Janssen Research and Development, Spring House, Pennsylvania, USA.
  • Lin-Schmidt X; Janssen BioTherapeutics, Janssen Research and Development, Spring House, Pennsylvania, USA.
  • Chin CN; Janssen BioTherapeutics, Janssen Research and Development, Spring House, Pennsylvania, USA.
  • Chavez JA; Cardiovascular and Metabolism Therapeutic Area, Janssen Research and Development, Spring House, Pennsylvania, USA.
  • Furman JL; Janssen BioTherapeutics, Janssen Research and Development, La Jolla, California, USA.
  • Armstrong AA; Janssen BioTherapeutics, Janssen Research and Development, Spring House, Pennsylvania, USA.
  • Beck SC; Cardiovascular and Metabolism Therapeutic Area, Janssen Research and Development, Spring House, Pennsylvania, USA.
  • South VJ; Janssen BioTherapeutics, Janssen Research and Development, Spring House, Pennsylvania, USA.
  • Dinh TQ; Janssen BioTherapeutics, Janssen Research and Development, La Jolla, California, USA.
  • Cash-Mason TD; Cardiovascular and Metabolism Therapeutic Area, Janssen Research and Development, Spring House, Pennsylvania, USA.
  • Cavanaugh CR; Cardiovascular and Metabolism Therapeutic Area, Janssen Research and Development, Spring House, Pennsylvania, USA.
  • Nelson S; Janssen BioTherapeutics, Janssen Research and Development, La Jolla, California, USA.
  • Huang C; Janssen BioTherapeutics, Janssen Research and Development, Spring House, Pennsylvania, USA.
  • Hunter MJ; Janssen BioTherapeutics, Janssen Research and Development, La Jolla, California, USA.
  • Rangwala SM; Cardiovascular and Metabolism Therapeutic Area, Janssen Research and Development, Spring House, Pennsylvania, USA.
Nat Med ; 23(10): 1150-1157, 2017 Oct.
Article en En | MEDLINE | ID: mdl-28846097
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pérdida de Peso / Ingestión de Alimentos / Receptores del Factor Neurotrófico Derivado de la Línea Celular Glial / Factor 15 de Diferenciación de Crecimiento / Obesidad Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pérdida de Peso / Ingestión de Alimentos / Receptores del Factor Neurotrófico Derivado de la Línea Celular Glial / Factor 15 de Diferenciación de Crecimiento / Obesidad Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos