Enteral nutrition as stress ulcer prophylaxis in critically ill patients: A randomized controlled exploratory study.
J Crit Care
; 43: 108-113, 2018 Feb.
Article
en En
| MEDLINE
| ID: mdl-28865339
ABSTRACT
PURPOSE:
We investigated whether early enteral nutrition alone may be sufficient prophylaxis against stress-related gastrointestinal (GI) bleeding in mechanically ventilated patients. MATERIALS ANDMETHODS:
Prospective, double blind, randomized, placebo-controlled, exploratory study that included mechanically ventilated patients in medical ICUs of two academic hospitals. Intravenous pantoprazole and early enteral nutrition were compared to placebo and early enteral nutrition as stress-ulcer prophylaxis. The incidences of clinically significant and overt GI bleeding were compared in the two groups.RESULTS:
124 patients were enrolled in the study. After exclusion of 22 patients, 102 patients were included inanalysis:
55 patients in the treatment group and 47 patients in the placebo group. Two patients (one from each group) showed signs of overt GI bleeding (overall incidence 1.96%), and both patients experienced a drop of >3 points in hematocrit in a 24-hour period indicating a clinically significant GI bleed. There was no statistical significant difference in the incidence of overt or significant GI bleeding between groups (p=0.99).CONCLUSION:
We found no benefit when pantoprazole is added to early enteral nutrition in mechanically ventilated critically ill patients. The routine prescription of acid-suppressive therapy in critically ill patients who tolerate early enteral nutrition warrants further evaluation.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Úlcera Péptica
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Nutrición Enteral
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2-Piridinilmetilsulfinilbencimidazoles
/
Inhibidores de la Bomba de Protones
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Hemorragia Gastrointestinal
/
Antiulcerosos
Tipo de estudio:
Clinical_trials
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Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Crit Care
Asunto de la revista:
TERAPIA INTENSIVA
Año:
2018
Tipo del documento:
Article