[Pharmacokinetics and tissue distribution of α-hederin sodium salt in rats].
Zhongguo Zhong Yao Za Zhi
; 41(13): 2543-2548, 2016 Jul.
Article
en Zh
| MEDLINE
| ID: mdl-28905583
ABSTRACT
To study the pharmacokinetics and tissue distribution characteristics of α-hederin sodium salt in rats. 100 mgâ¢kg⻹ α-hederin sodium salt was given to the rats by intragastric administration, and LC-MS/MS method was used to determine its concentration at different time in plasma and tissues. Plasma and tissue samples were treated with methanol protein deposition method. Main pharmacokinetic parameters were as followsï¼ tmax (0.97±1.23) h, Cmax (222.53±57.28) µgâ¢L⻹, AUC0-t (1 262±788.9) h⢵gâ¢L⻹, T1/2 (17.94±9.50) h. α-hederin can be detected in heart, liver, spleen, lung, kidney, brain, muscle and adipose. The results showed that α-hederin sodium salt was absorbed fast and eliminated slowly in rats after oral administration. It was widely distributed in body tissues and livers kept the highest concentrations among various tissues at different time, so it can be speculated that α-hederin may have certain targeting property on livers.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácido Oleanólico
/
Saponinas
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Asunto de la revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Año:
2016
Tipo del documento:
Article
País de afiliación:
China