Bronchoprotective effect of deep inspirations in cough variant asthma: A distinguishing feature in the spectrum of airway disease?
Respir Physiol Neurobiol
; 257: 55-64, 2018 11.
Article
en En
| MEDLINE
| ID: mdl-28917529
ABSTRACT
PURPOSE:
To assess the effect of deep inspirations (DIs) on airway behaviour in individuals with classic asthma (CA), cough variant asthma (CVA), and methacholine (MCh)-induced cough but normal airway sensitivity (COUGH) during bronchoprovocation.METHODS:
Twenty-five adults (18 female; 44.8⯱â¯12.3â¯years (Mean⯱â¯SD); nâ¯=â¯9 CA, nâ¯=â¯9 CVA, and nâ¯=â¯7 COUGH) completed two single-dose MCh challenges, with and without DIs. Bronchoprotection was assessed by comparing changes in bronchoconstriction (FEV1, FVC, FEV1/FVC, FEF50, FEF25-75), gas trapping (RV, RV/TLC) and impulse oscillometry (IOS) measurements.RESULTS:
The% changes in FEV1 with and without DIs were not significantly different within any group. Decreases in FEF50 and FEF25-75 were greater in CA (pâ¯=â¯0.041 and pâ¯=â¯0.029), decreases in FVC (% predicted) and FEV1/FVC(%) were less in CVA (pâ¯=â¯0.048 and pâ¯=â¯0.010), and increases in RV (L) and RV/TLC (% predicted) were less in COUGH (pâ¯=â¯0.007 and pâ¯=â¯0.028), respectively. No differences in IOS measurements were noted.CONCLUSIONS:
DIs triggered bronchoconstriction in CA, bronchoprotection in CVA, and prevented gas trapping in COUGH.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Asma
/
Inhalación
/
Tos
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Respir Physiol Neurobiol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Canadá