Instructed subsets or agile swarms: how T-helper cells may adaptively counter uncertainty with variability and plasticity.
Curr Opin Genet Dev
; 47: 75-82, 2017 Dec.
Article
en En
| MEDLINE
| ID: mdl-28926759
ABSTRACT
Over recent years, extensive phenotypic variability and plasticity have been revealed among the T-helper cells of the mammalian adaptive immune system, even within clonal lineages of identical antigen specificity. This challenges the conventional view that T-helper cells assort into functionally distinct subsets following differential instruction by the innate immune system. We argue that the adaptive value of coping with uncertainty can reconcile the 'instructed subset' framework with T-helper variability and plasticity. However, we also suggest that T-helper cells might better be understood as agile swarms engaged in collective decision-making to promote host fitness. With rigorous testing, the 'agile swarms' framework may illuminate how variable and plastic individual T-helper cells interact to create coherent immunity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Subgrupos de Linfocitos T
/
Linfocitos T Colaboradores-Inductores
/
Inmunidad Adaptativa
/
Plasticidad de la Célula
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Curr Opin Genet Dev
Asunto de la revista:
GENETICA
Año:
2017
Tipo del documento:
Article