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Lissodendoric Acids A and B, Manzamine-Related Alkaloids from the Far Eastern Sponge Lissodendoryx florida.
Lyakhova, Ekaterina G; Kolesnikova, Sophia A; Kalinovsky, Anatoly I; Berdyshev, Dmitrii V; Pislyagin, Evgeny A; Kuzmich, Aleksandra S; Popov, Roman S; Dmitrenok, Pavel S; Makarieva, Tatyana N; Stonik, Valentin A.
Afiliación
  • Lyakhova EG; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, The Far East Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159, Vladivostok-22, Russia.
  • Kolesnikova SA; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, The Far East Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159, Vladivostok-22, Russia.
  • Kalinovsky AI; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, The Far East Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159, Vladivostok-22, Russia.
  • Berdyshev DV; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, The Far East Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159, Vladivostok-22, Russia.
  • Pislyagin EA; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, The Far East Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159, Vladivostok-22, Russia.
  • Kuzmich AS; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, The Far East Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159, Vladivostok-22, Russia.
  • Popov RS; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, The Far East Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159, Vladivostok-22, Russia.
  • Dmitrenok PS; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, The Far East Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159, Vladivostok-22, Russia.
  • Makarieva TN; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, The Far East Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159, Vladivostok-22, Russia.
  • Stonik VA; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, The Far East Branch of the Russian Academy of Sciences , Prospect 100-let Vladivostoku 159, Vladivostok-22, Russia.
Org Lett ; 19(19): 5320-5323, 2017 10 06.
Article en En | MEDLINE | ID: mdl-28933163
ABSTRACT
The first representatives of a new group of manzamine-related alkaloids with a previously unknown skeletal systems, namely, lissodendoric acids A (1) and B (2), were isolated from the sponge Lissodendoryx florida collected from the Sea of Okhotsk. The structures and absolute configurations have been elucidated by extensive spectroscopic analysis together with chemical transformations and quantum-chemical modeling. The lissodendoric acids show a potent capability to decrease the production of reactive oxygen species in neuroblastoma Neuro 2a and somewhat increase the survival of these cells upon treatment with 6-hydroxydopamine (an in vitro antiparkinson biotest).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcaloides Límite: Animals Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Rusia
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcaloides Límite: Animals Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Rusia