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Purity of islet preparations and 5-year metabolic outcome of allogenic islet transplantation.
Benomar, K; Chetboun, M; Espiard, S; Jannin, A; Le Mapihan, K; Gmyr, V; Caiazzo, R; Torres, F; Raverdy, V; Bonner, C; D'Herbomez, M; Pigny, P; Noel, C; Kerr-Conte, J; Pattou, F; Vantyghem, M C.
Afiliación
  • Benomar K; Department of Endocrinology and Metabolism, CHRU Lille, Lille, France.
  • Chetboun M; UMR 1190, Translational Research in Diabetes INSERM, Lille, France.
  • Espiard S; EGID (European Genomic Institute for Diabetes), Univ Lille, Lille, France.
  • Jannin A; UMR 1190, Translational Research in Diabetes INSERM, Lille, France.
  • Le Mapihan K; EGID (European Genomic Institute for Diabetes), Univ Lille, Lille, France.
  • Gmyr V; Department of Endocrine Surgery, CHRU Lille, Lille, France.
  • Caiazzo R; Department of Endocrinology and Metabolism, CHRU Lille, Lille, France.
  • Torres F; Department of Endocrinology and Metabolism, CHRU Lille, Lille, France.
  • Raverdy V; Department of Endocrinology and Metabolism, CHRU Lille, Lille, France.
  • Bonner C; UMR 1190, Translational Research in Diabetes INSERM, Lille, France.
  • D'Herbomez M; EGID (European Genomic Institute for Diabetes), Univ Lille, Lille, France.
  • Pigny P; UMR 1190, Translational Research in Diabetes INSERM, Lille, France.
  • Noel C; EGID (European Genomic Institute for Diabetes), Univ Lille, Lille, France.
  • Kerr-Conte J; Department of Endocrine Surgery, CHRU Lille, Lille, France.
  • Pattou F; UMR 1190, Translational Research in Diabetes INSERM, Lille, France.
  • Vantyghem MC; EGID (European Genomic Institute for Diabetes), Univ Lille, Lille, France.
Am J Transplant ; 18(4): 945-951, 2018 04.
Article en En | MEDLINE | ID: mdl-28941330
ABSTRACT
In allogenic islet transplantation (IT), high purity of islet preparations and low contamination by nonislet cells are generally favored. The aim of the present study was to analyze the relation between the purity of transplanted preparations and graft function during 5 years post-IT. Twenty-four patients with type 1 diabetes, followed for 5 years after IT, were enrolled. Metabolic parameters and daily insulin requirements were compared between patients who received islet preparations with a mean purity <50% (LOW purity) or ≥50% (HIGH purity). We also analyzed blood levels of carbohydrate antigen 19-9 (CA 19-9)-a biomarker of pancreatic ductal cells-and glucagon, before and after IT. At 5 years, mean hemoglobin A1c (HbA1c levels) (P = .01) and daily insulin requirements (P = .03) were lower in the LOW purity group. Insulin independence was more frequent in the LOW purity group (P < .05). CA19-9 and glucagon levels increased post-IT (P < .0001) and were inversely correlated with the degree of purity. Overall, our results suggest that nonislet cells have a beneficial effect on long-term islet graft function, possibly through ductal-to-endocrine cell differentiation. ClinicalTrial.gov NCT00446264 and NCT01123187.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Hemoglobina Glucada / Separación Celular / Trasplante de Islotes Pancreáticos / Islotes Pancreáticos / Diabetes Mellitus Tipo 1 / Supervivencia de Injerto Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2018 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Hemoglobina Glucada / Separación Celular / Trasplante de Islotes Pancreáticos / Islotes Pancreáticos / Diabetes Mellitus Tipo 1 / Supervivencia de Injerto Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2018 Tipo del documento: Article País de afiliación: Francia