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Formaldehyde Inhibits Sexual Behavior and Expression of Steroidogenic Enzymes in the Testes of Mice.
Zang, Zhi-Jun; Fang, You-Qiang; Ji, Su-Yun; Gao, Yong; Zhu, Yuan-Qiang; Xia, Ting-Ting; Jiang, Mei-Hua; Zhang, Ya-Nan.
Afiliación
  • Zang ZJ; Department of Infertility and Sexual Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China. Electronic address: zangzhijun@163.com.
  • Fang YQ; Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
  • Ji SY; Department of Dermatology, Guangdong Provincial Dermatology Hospital, Guangzhou, People's Republic of China.
  • Gao Y; Reproductive Medicine Centre and Guangdong Provincial Key Laboratory of Reproductive Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
  • Zhu YQ; Department of Infertility and Sexual Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
  • Xia TT; Department of Infertility and Sexual Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
  • Jiang MH; Department of Anatomy, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.
  • Zhang YN; Department of Infertility and Sexual Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
J Sex Med ; 14(11): 1297-1306, 2017 11.
Article en En | MEDLINE | ID: mdl-28943032
BACKGROUND: Formaldehyde, a ubiquitous environmental pollutant, is used extensively and has been proved to impair male reproduction in mammals. However, no trials have explored whether formaldehyde affects sexual function. AIM: To evaluate the effect of long-term formaldehyde exposure on sexual behavior and to investigate the potential mechanism. METHODS: Forty C57BL/6 male mice were randomly allocated to four equally sized groups. Mice were exposed to formaldehyde at a dose of 0 (control), 0.5, 5.0, or 10.0 mg/m3 by inhalation for 60 days. OUTCOMES: Sexual behavior, body and reproductive organ weights, testosterone concentration in serum and testicular tissue, expression of steroidogenic enzymes, quality of sperm, and testicular structure were measured. RESULTS: Formaldehyde inhibited sexual behavior and decreased reproductive organ weights in mice. Serum testosterone levels and intratesticular testosterone concentrations were decreased in the formaldehyde-treated groups. Expression levels of steroidogenic enzymes, including steroidogenic acute regulatory protein, cytochrome P450 cholesterol side-chain cleavage enzyme, and 3ß-hydroxysteroid dehydrogenase (3ß-HSD), also were decreased in the testes of mice exposed to formaldehyde. Moreover, the structure of seminiferous tubules was destroyed and sperm quality decreased after formaldehyde exposure. In addition, the results indicated that the effects of formaldehyde were dose dependent. CLINICAL IMPLICATIONS: Efforts should be undertaken to decrease impairment of sexual function caused by formaldehyde exposure. STRENGTHS AND LIMITATIONS: The relatively small sample might have affected the outcomes. Further experiments are needed to study the mechanism of action of formaldehyde. CONCLUSION: Exposure to formaldehyde gas inhibited sexual behavior, caused reproductive organ atrophy, and impaired spermatogenesis in male mice, which might have been induced by suppressed expression of steroidogenic enzymes in Leydig cells and decreased testosterone synthesis. Zang Z-J, Fang Y-Q, Ji S-Y, et al. Formaldehyde Inhibits Sexual Behavior and Expression of Steroidogenic Enzymes in the Testes of Mice. J Sex Med 2017;14:1297-1306.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfoproteínas / Conducta Sexual Animal / Espermatozoides / Testículo / Formaldehído Límite: Animals Idioma: En Revista: J Sex Med Asunto de la revista: GINECOLOGIA / MEDICINA REPRODUTIVA / UROLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfoproteínas / Conducta Sexual Animal / Espermatozoides / Testículo / Formaldehído Límite: Animals Idioma: En Revista: J Sex Med Asunto de la revista: GINECOLOGIA / MEDICINA REPRODUTIVA / UROLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos