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Dab1 contributes differently to the morphogenesis of the hippocampal subdivisions.
Blume, Marissa; Inoguchi, Fuduki; Sugiyama, Taku; Owada, Yuji; Osumi, Noriko; Aimi, Yoshinari; Taki, Kosuke; Katsuyama, Yu.
Afiliación
  • Blume M; School for Mental Health and Neuroscience, European Graduate School of Neuroscience, Maastricht University, Maastricht, 6229 ER, The Netherlands.
  • Inoguchi F; Department of Developmental Neuroscience, Graduate School of Medicine, Tohoku University, Sendai, 980-8575, Japan.
  • Sugiyama T; Department of Anatomy, Shiga University of Medical Science, Otsu, 520-2192, Japan.
  • Owada Y; Department of Developmental Neuroscience, Graduate School of Medicine, Tohoku University, Sendai, 980-8575, Japan.
  • Osumi N; Department of Organ Anatomy, Graduate School of Medicine, Tohoku University, Sendai, 980-8575, Japan.
  • Aimi Y; Department of Developmental Neuroscience, Graduate School of Medicine, Tohoku University, Sendai, 980-8575, Japan.
  • Taki K; Department of Anatomy, Shiga University of Medical Science, Otsu, 520-2192, Japan.
  • Katsuyama Y; Department of Anatomy, Shiga University of Medical Science, Otsu, 520-2192, Japan.
Dev Growth Differ ; 59(8): 657-673, 2017 Oct.
Article en En | MEDLINE | ID: mdl-28945921
The hippocampal formation (HF) is morphologically and functionally distinguishable into the subdivisions, such as the dentate gyrus (DG), subiculum, and Ammon's horn. The Ammon's horn is further divided into the CA (Cornu Ammonis)1, CA2, and CA3. The Reelin-Dab1 signal is essential for the morphogenesis of the mammalian brain. In the neocortex of Reelin-Dab1 signal mutants the laminar pattern of the neurons is disrupted along the radial axis. Morphological abnormalities in the HF of the Reelin-Dab1 mutants were known, but how these abnormalities appear during development had not been extensively studied. We examined the morphology of the well-developed Dab1 deficient HF by staining with a silver impregnation method in this report, and found that disruption of lamination in the CA1, CA3, and DG was different. Abnormalities observed in the development of Dab1 deficient CA1 were similar to those reported in the neocortical development, while Dab1 deficient CA3 neuronal progenitors radially spreaded beyond presumptive pyramidal layer. The intermediate progenitor cells ectopically located in the Dab1 deficient DG, but neurogenesis was normal in the CA1 and CA3. These observations suggest that the morphogenesis in these HF subdivisions employs different developmental mechanisms involving Dab1 function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Embrión de Mamíferos / Neurogénesis / Región CA1 Hipocampal / Región CA3 Hipocampal / Células-Madre Neurales / Proteínas del Tejido Nervioso Límite: Animals Idioma: En Revista: Dev Growth Differ Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Japón

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Embrión de Mamíferos / Neurogénesis / Región CA1 Hipocampal / Región CA3 Hipocampal / Células-Madre Neurales / Proteínas del Tejido Nervioso Límite: Animals Idioma: En Revista: Dev Growth Differ Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Japón