A dynorphin peptide induces hypotension by stimulating the release of atrial natriuretic peptide from rat atrium.
Life Sci
; 42(11): 1117-22, 1988.
Article
en En
| MEDLINE
| ID: mdl-2894603
ABSTRACT
Intravenous injection of dynorphin A-(1-10) amide (Dyn, 81-324 nmol/kg) induced a dose-dependent hypotensive effect in the rat. This effect was antagonized by pretreatment with immunoglobulin G, purified from a specific antiserum raised against alpha-human atrial natriuretic peptide (anti-hANP-IgG), as well as by high doses of naloxone (2 or 10 mg/kg). In addition, a 12-fold increase in plasma level of atrial natriuretic peptide-like immunoreactivity (ANP-IR) was found following Dyn administration, which was accompanied by a significant decrease of atrial ANP-IR. These results suggest that the stimulated release of ANP-IR from the atrium may constitute one of the mechanisms for the depressor effect of dynorphin peptides.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Dinorfinas
/
Factor Natriurético Atrial
/
Hipotensión
/
Miocardio
Límite:
Animals
Idioma:
En
Revista:
Life Sci
Año:
1988
Tipo del documento:
Article
País de afiliación:
China