Molecular Pathogenesis of Myeloproliferative Neoplasms: Influence of Age and Gender.
Curr Hematol Malig Rep
; 12(5): 424-431, 2017 10.
Article
en En
| MEDLINE
| ID: mdl-28948454
ABSTRACT
The myeloproliferative neoplasms polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) display distinct clinical and pathologic features but are characterized by mutations in JAK2, MPL, and CALR leading to activation of the JAK-STAT pathway. This review addresses the pathogenesis and mechanisms of these mutant alleles and the unique interactions of both of age and gender.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Caracteres Sexuales
/
Janus Quinasa 2
/
Receptores de Trombopoyetina
/
Mutación
/
Trastornos Mieloproliferativos
Tipo de estudio:
Etiology_studies
Aspecto:
Determinantes_sociais_saude
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Curr Hematol Malig Rep
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos