Progress in understanding mucus abnormalities in cystic fibrosis airways.
J Cyst Fibros
; 17(2S): S35-S39, 2018 03.
Article
en En
| MEDLINE
| ID: mdl-28951068
ABSTRACT
Normal airways below the carina maintain an essentially sterile environment via a multi-pronged innate defence system that includes mucus clearance via mucociliary clearance and cough, multiple antimicrobials and cellular components including macrophages and neutrophils. In cystic fibrosis (CF), loss of CFTR function compromises these defences, and with present standard of care virtually all people with CF eventually develop mucus accumulation, plugging and chronic infections. This review focuses on how mucus is affected by CFTR loss.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Depuración Mucociliar
/
Regulador de Conductancia de Transmembrana de Fibrosis Quística
/
Fibrosis Quística
Límite:
Humans
Idioma:
En
Revista:
J Cyst Fibros
Año:
2018
Tipo del documento:
Article