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A novel role for SALL4 during scar-free wound healing in axolotl.
Erickson, Jami R; Gearhart, Micah D; Honson, Drew D; Reid, Taylor A; Gardner, Melissa K; Moriarity, Branden S; Echeverri, Karen.
Afiliación
  • Erickson JR; Department of Genetics, Cell Biology and Development, University of Minnesota, Minnesota, MN, USA.
  • Gearhart MD; Department of Genetics, Cell Biology and Development, University of Minnesota, Minnesota, MN, USA.
  • Honson DD; Department of Genetics, Cell Biology and Development, University of Minnesota, Minnesota, MN, USA.
  • Reid TA; Department of Genetics, Cell Biology and Development, University of Minnesota, Minnesota, MN, USA.
  • Gardner MK; Department of Genetics, Cell Biology and Development, University of Minnesota, Minnesota, MN, USA.
  • Moriarity BS; Department of Pediatrics, University of Minnesota, Center for Genome Engineering, University of Minnesota, Masonic Cancer Center, University of Minnesota, Minnesota, MN USA.
  • Echeverri K; Department of Genetics, Cell Biology and Development, University of Minnesota, Minnesota, MN, USA.
NPJ Regen Med ; 12016.
Article en En | MEDLINE | ID: mdl-28955504
The human response to serious cutaneous damage is limited to relatively primitive wound healing, whereby collagenous scar tissue fills the wound bed. Scars assure structural integrity at the expense of functional regeneration. In contrast, axolotls have the remarkable capacity to functionally regenerate full thickness wounds. Here, we identified a novel role for SALL4 in regulating collagen transcription after injury that is essential for perfect skin regeneration in axolotl. Furthermore, we identify miR-219 as a molecular regulator of Sall4 during wound healing. Taken together, our work highlights one molecular mechanism that allows for efficient cutaneous wound healing in the axolotl.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NPJ Regen Med Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NPJ Regen Med Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos