Phenolic excipients of insulin formulations induce cell death, pro-inflammatory signaling and MCP-1 release.
Toxicol Rep
; 2: 194-202, 2015.
Article
en En
| MEDLINE
| ID: mdl-28962351
APC, allophycocyanin; Adverse effects; Apidra (PubChem CID: 72941761); CCL2, chemokine ligand 2; CD, cluster of differentiation; CSII, continuous subcutaneous insulin infusion; DMSO, dimethyl sulfoxide; ERK, extracellular signal-regulated kinase; Humalog (PubChem CID: 16132438); IL, interleukin; IgG, immunoglobulin G; Inflammation; Insulin; Insulin (PubChem CID: 70678557); JNK, Jun N-terminal kinase; MAP kinase, mitogen-activated protein kinase; MCP-1; MCP-1, monocyte chemotactic protein-1; Mip-1α, macrophage inflammatory protein-1alpha; NovoRapid (PubChem CID: 16132418); PE, phycoerythrin; Phenol (PubChem CID: 996); Phenolic excipients; TNFα, tumor necrosis factor alpha; XTT, 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide; m-Cresol (PubChem CID: 342)
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Toxicol Rep
Año:
2015
Tipo del documento:
Article
País de afiliación:
Alemania