Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions.
Proc Natl Acad Sci U S A
; 85(9): 3245-9, 1988 May.
Article
en En
| MEDLINE
| ID: mdl-2896357
ABSTRACT
Autoradiographic studies localize [3H]bradykinin receptor binding sites to the substantia gelatinosa, dorsal root, and a subset of small cells in both the dorsal root and trigeminal ganglia of the guinea pig. [3H]Bradykinin labeling is also observed over myocardial/coronary visceral afferent fibers. The localization of [3H]bradykinin receptors to nociceptive pathways supports a role for bradykinin in pain mediation. Several bradykinin antagonists block bradykinin-induced acute vascular pain in the rat. The bradykinin antagonists also relieve bradykinin- and urate-induced hyperalgesia in the rat paw. These results indicate that bradykinin is a physiologic mediator of pain and that bradykinin antagonists have analgesic activity in both acute and chronic pain models.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dolor
/
Bradiquinina
/
Receptores de Neurotransmisores
/
Analgesia
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Año:
1988
Tipo del documento:
Article