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Determination of complete sequence information of the human ABO blood group orthologous gene in pigs and breed difference in blood type frequencies.
Choi, Min-Kyeung; Le, Minh Thong; Cho, Hyesun; Yum, Joori; Kang, Mingue; Song, Hyuk; Kim, Jin-Hoi; Chung, Hak Jae; Hong, Kwonho; Park, Chankyu.
Afiliación
  • Choi MK; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea.
  • Le MT; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea.
  • Cho H; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea.
  • Yum J; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea.
  • Kang M; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea.
  • Song H; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea; Humanized Pig Research Center (SRC), 120 Neungdong-ro, Gwangjin-gu, Seoul, South Korea.
  • Kim JH; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea; Humanized Pig Research Center (SRC), 120 Neungdong-ro, Gwangjin-gu, Seoul, South Korea.
  • Chung HJ; Animal Biotechnology Division, National Institute of Animal Science, RDA, Wanju-gun, South Korea.
  • Hong K; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea; Humanized Pig Research Center (SRC), 120 Neungdong-ro, Gwangjin-gu, Seoul, South Korea. Electronic address: hongk@konkuk.ac.kr.
  • Park C; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea; Humanized Pig Research Center (SRC), 120 Neungdong-ro, Gwangjin-gu, Seoul, South Korea. Electronic address: chankyu@konkuk.ac.kr.
Gene ; 640: 1-5, 2018 Jan 15.
Article en En | MEDLINE | ID: mdl-28966132
ABSTRACT
The sequence information of the genomic form of the human ABO blood group orthologous gene (erythrocyte antigen A, EAA) is not complete in pigs. Therefore, we cloned and characterized the nucleotide sequence of EAA intron 7, which is critical to understand genetic difference between A and 0 blood groups in pigs, covering complete genomic sequence information of EAA excluding a ~560bp unsequencible gap. We also analyzed genetic polymorphisms within EAA intron 7 and exon 8. We found difference in A0 blood group frequencies among pig breeds. In addition, we designed a new genomic DNA-based A0 blood group typing method and improved the accuracy and simplicity of the typing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Sistema del Grupo Sanguíneo ABO / Cruzamiento / Análisis de Secuencia de ADN Límite: Animals / Humans Idioma: En Revista: Gene Año: 2018 Tipo del documento: Article País de afiliación: Corea del Sur
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Sistema del Grupo Sanguíneo ABO / Cruzamiento / Análisis de Secuencia de ADN Límite: Animals / Humans Idioma: En Revista: Gene Año: 2018 Tipo del documento: Article País de afiliación: Corea del Sur