Structural-functional analysis of engineered protein-nanoparticle assemblies using graphene microelectrodes.
Chem Sci
; 8(8): 5329-5334, 2017 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-28970912
ABSTRACT
The characterization of protein-nanoparticle assemblies in solution remains a challenge. We demonstrate a technique based on a graphene microelectrode for structural-functional analysis of model systems composed of nanoparticles enclosed in open-pore and closed-pore ferritin molecules. The method readily resolves the difference in accessibility of the enclosed nanoparticle for charge transfer and offers the prospect for quantitative analysis of pore-mediated transport, while shedding light on the spatial orientation of the protein subunits on the nanoparticle surface, faster and with higher sensitivity than conventional catalysis methods.
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01-internacional
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MEDLINE
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En
Revista:
Chem Sci
Año:
2017
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Article