Interphasic nucleolar organizer region distribution as a diagnostic parameter to differentiate benign from malignant epithelial tumors of human intestine.
Virchows Arch B Cell Pathol Incl Mol Pathol
; 54(6): 334-40, 1988.
Article
en En
| MEDLINE
| ID: mdl-2897741
ABSTRACT
The distribution of the interphasic nucleolar organizer regions (NORs) has been investigated in five hyperplastic polyps, five adenomatous polyps and fifteen colonic adenocarcinomas. The study was performed using electron microscopy and paraffin-embedded sections stained for Ag-NOR proteins. Malignant tumor cells were characterized by a large number of NORs which were small in size and showed a scattered distribution. Nuclei of both types of polyp had only a small number of large-sized NORs in a clustered distribution. In two adenomatous polyps, cells were also observed with an NOR distribution pattern intermediate between that of frankly benign and malignant lesions.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Adenocarcinoma
/
Adenoma
/
Pólipos del Colon
/
Colon
/
Neoplasias del Colon
/
Región Organizadora del Nucléolo
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Virchows Arch B Cell Pathol Incl Mol Pathol
Año:
1988
Tipo del documento:
Article
País de afiliación:
Italia