Physiopathological roles of spontaneously released outer membrane vesicles of Bordetella pertussis.
Future Microbiol
; 12: 1247-1259, 2017 11.
Article
en En
| MEDLINE
| ID: mdl-28980823
ABSTRACT
AIM:
Bordetella pertussis has been shown to release outer membrane vesicles (OMV) both in vitro and in vivo but little is known about their biological role during the initial phases of B. pertussis infection of the airways.RESULTS:
We have demonstrated that OMV are released by B. pertussis in a human ciliated-airway cell model and purified vesicles can interact with host cells. Binding and uptake are strictly Bvg-regulated and OMV-associated pertussis toxin contributes to host-cell intoxication. Furthermore, we have shown that OMV act as iron-delivery systems complementing the B. pertussis growth defect in iron-limiting conditions.CONCLUSION:
We have proved that OMV play different roles in B. pertussis physiopathology and we opened new perspectives to be further investigated.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de la Membrana Bacteriana Externa
/
Bordetella pertussis
/
Membrana Celular
/
Tos Ferina
/
Toxina del Pertussis
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Future Microbiol
Asunto de la revista:
MICROBIOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia