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HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients.
Guo, Wenting; Naujock, Maximilian; Fumagalli, Laura; Vandoorne, Tijs; Baatsen, Pieter; Boon, Ruben; Ordovás, Laura; Patel, Abdulsamie; Welters, Marc; Vanwelden, Thomas; Geens, Natasja; Tricot, Tine; Benoy, Veronick; Steyaert, Jolien; Lefebvre-Omar, Cynthia; Boesmans, Werend; Jarpe, Matthew; Sterneckert, Jared; Wegner, Florian; Petri, Susanne; Bohl, Delphine; Vanden Berghe, Pieter; Robberecht, Wim; Van Damme, Philip; Verfaillie, Catherine; Van Den Bosch, Ludo.
Afiliación
  • Guo W; KU Leuven-Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), Leuven, 3000, Belgium.
  • Naujock M; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Leuven, 3000, Belgium.
  • Fumagalli L; Department of Neurology, Hannover Medical School, Hannover, 30625, Germany.
  • Vandoorne T; CNS Research Department, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, 88400, Germany.
  • Baatsen P; KU Leuven-Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), Leuven, 3000, Belgium.
  • Boon R; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Leuven, 3000, Belgium.
  • Ordovás L; KU Leuven-Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), Leuven, 3000, Belgium.
  • Patel A; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Leuven, 3000, Belgium.
  • Welters M; VIB Bio Imaging Core and VIB-KU Leuven, Center for Brain and Disease Research, Leuven, 3000, Belgium.
  • Vanwelden T; KU Leuven-Stem Cell Institute (SCIL), Leuven, 3000, Belgium.
  • Geens N; KU Leuven-Stem Cell Institute (SCIL), Leuven, 3000, Belgium.
  • Tricot T; Aragon I+D Foundation (ARAID), Zaragoza, 50018, Spain.
  • Benoy V; Biomedical Signal Interpretation and Computational Simulation (BSICoS) Group, Aragon Institute of Engineering Research, IIS Aragón, University of Zaragoza, Zaragoza, 50018, Spain.
  • Steyaert J; KU Leuven-Stem Cell Institute (SCIL), Leuven, 3000, Belgium.
  • Lefebvre-Omar C; KU Leuven-Stem Cell Institute (SCIL), Leuven, 3000, Belgium.
  • Boesmans W; KU Leuven-Stem Cell Institute (SCIL), Leuven, 3000, Belgium.
  • Jarpe M; KU Leuven-Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), Leuven, 3000, Belgium.
  • Sterneckert J; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Leuven, 3000, Belgium.
  • Wegner F; KU Leuven-Stem Cell Institute (SCIL), Leuven, 3000, Belgium.
  • Petri S; KU Leuven-Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), Leuven, 3000, Belgium.
  • Bohl D; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Leuven, 3000, Belgium.
  • Vanden Berghe P; KU Leuven-Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), Leuven, 3000, Belgium.
  • Robberecht W; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Leuven, 3000, Belgium.
  • Van Damme P; Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 6, Institut du Cerveau et de la Moelle épinière (ICM), Hôpital Pitié-Salpêtrière, Paris, 75013, France.
  • Verfaillie C; Lab for Enteric NeuroScience, TARGID, KU Leuven, Leuven, 3000, Belgium.
  • Van Den Bosch L; Acetylon Pharmaceuticals Inc., Boston, MA, 02210, USA.
Nat Commun ; 8(1): 861, 2017 10 11.
Article en En | MEDLINE | ID: mdl-29021520
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transporte Axonal / Proteína FUS de Unión a ARN / Histona Desacetilasa 6 / Esclerosis Amiotrófica Lateral / Neuronas Motoras Límite: Adolescent / Adult / Aged / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transporte Axonal / Proteína FUS de Unión a ARN / Histona Desacetilasa 6 / Esclerosis Amiotrófica Lateral / Neuronas Motoras Límite: Adolescent / Adult / Aged / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido