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Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity.
Uliassi, Elisa; Fiorani, Giulia; Krauth-Siegel, R Luise; Bergamini, Christian; Fato, Romana; Bianchini, Giulia; Carlos Menéndez, J; Molina, Maria Teresa; López-Montero, Eulogio; Falchi, Federico; Cavalli, Andrea; Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Witt, Gesa; Moraes, Carolina B; Freitas-Junior, Lucio H; Borsari, Chiara; Costi, Maria Paola; Bolognesi, Maria Laura.
Afiliación
  • Uliassi E; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6 and Via Irnerio 48, 40126 Bologna, Italy.
  • Fiorani G; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6 and Via Irnerio 48, 40126 Bologna, Italy; Biochemie-Zentrum der Universität Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
  • Krauth-Siegel RL; Biochemie-Zentrum der Universität Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
  • Bergamini C; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6 and Via Irnerio 48, 40126 Bologna, Italy.
  • Fato R; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6 and Via Irnerio 48, 40126 Bologna, Italy.
  • Bianchini G; Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, Plaza de Ramón y Cajal, 28040 Madrid, Spain.
  • Carlos Menéndez J; Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, Plaza de Ramón y Cajal, 28040 Madrid, Spain.
  • Molina MT; Instituto de Química Médica (IQM-CSIC), C/Juan de La Cierva 3, 28006 Madrid, Spain.
  • López-Montero E; Instituto de Química Médica (IQM-CSIC), C/Juan de La Cierva 3, 28006 Madrid, Spain.
  • Falchi F; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6 and Via Irnerio 48, 40126 Bologna, Italy; CompuNet, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.
  • Cavalli A; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6 and Via Irnerio 48, 40126 Bologna, Italy; CompuNet, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.
  • Gul S; Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, D-22525 Hamburg, Germany.
  • Kuzikov M; Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, D-22525 Hamburg, Germany.
  • Ellinger B; Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, D-22525 Hamburg, Germany.
  • Witt G; Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, D-22525 Hamburg, Germany.
  • Moraes CB; Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa Em Energia e Materiais (CNPEM), SP13083-100 Campinas, Brazil.
  • Freitas-Junior LH; Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa Em Energia e Materiais (CNPEM), SP13083-100 Campinas, Brazil.
  • Borsari C; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
  • Costi MP; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
  • Bolognesi ML; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6 and Via Irnerio 48, 40126 Bologna, Italy. Electronic address: marialaura.bolognesi@unibo.it.
Eur J Med Chem ; 141: 138-148, 2017 Dec 01.
Article en En | MEDLINE | ID: mdl-29031061
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinonas / Tripanocidas / Trypanosoma brucei brucei / Trypanosoma cruzi / Gliceraldehído-3-Fosfato Deshidrogenasas / NADH NADPH Oxidorreductasas Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2017 Tipo del documento: Article País de afiliación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinonas / Tripanocidas / Trypanosoma brucei brucei / Trypanosoma cruzi / Gliceraldehído-3-Fosfato Deshidrogenasas / NADH NADPH Oxidorreductasas Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2017 Tipo del documento: Article País de afiliación: Italia