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Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.
Sobotta, Svantje; Raue, Andreas; Huang, Xiaoyun; Vanlier, Joep; Jünger, Anja; Bohl, Sebastian; Albrecht, Ute; Hahnel, Maximilian J; Wolf, Stephanie; Mueller, Nikola S; D'Alessandro, Lorenza A; Mueller-Bohl, Stephanie; Boehm, Martin E; Lucarelli, Philippe; Bonefas, Sandra; Damm, Georg; Seehofer, Daniel; Lehmann, Wolf D; Rose-John, Stefan; van der Hoeven, Frank; Gretz, Norbert; Theis, Fabian J; Ehlting, Christian; Bode, Johannes G; Timmer, Jens; Schilling, Marcel; Klingmüller, Ursula.
Afiliación
  • Sobotta S; Division Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany.
  • Raue A; Discovery Division, Merrimack Pharmaceuticals, Cambridge, MA, United States.
  • Huang X; Division Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany.
  • Vanlier J; Institute of Physics, Albert Ludwigs University of Freiburg, Freiburg, Germany.
  • Jünger A; BIOSS Centre for Biological Signalling Studies, Albert Ludwigs University of Freiburg, Freiburg, Germany.
  • Bohl S; Division Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany.
  • Albrecht U; Division Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany.
  • Hahnel MJ; Clinic of Gastroenterology, Hepatology and Infectious Diseases, University Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
  • Wolf S; Clinic of Gastroenterology, Hepatology and Infectious Diseases, University Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
  • Mueller NS; Clinic of Gastroenterology, Hepatology and Infectious Diseases, University Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
  • D'Alessandro LA; Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.
  • Mueller-Bohl S; Division Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany.
  • Boehm ME; Division Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany.
  • Lucarelli P; Division Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany.
  • Bonefas S; Division Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany.
  • Damm G; Division Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany.
  • Seehofer D; Department of Hepatobiliary Surgery and Visceral Transplantation, Leipzig University, Leipzig, Germany.
  • Lehmann WD; Department of Hepatobiliary Surgery and Visceral Transplantation, Leipzig University, Leipzig, Germany.
  • Rose-John S; Division Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany.
  • van der Hoeven F; Institute of Biochemistry, University of Kiel, Kiel, Germany.
  • Gretz N; Transgenic Service, Center for Preclinical Research, German Cancer Research Center, Heidelberg, Germany.
  • Theis FJ; Medical Research Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Ehlting C; Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.
  • Bode JG; Department of Mathematics, Technical University of Munich, Garching, Germany.
  • Timmer J; Clinic of Gastroenterology, Hepatology and Infectious Diseases, University Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
  • Schilling M; Clinic of Gastroenterology, Hepatology and Infectious Diseases, University Hospital, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.
  • Klingmüller U; Institute of Physics, Albert Ludwigs University of Freiburg, Freiburg, Germany.
Front Physiol ; 8: 775, 2017.
Article en En | MEDLINE | ID: mdl-29062282
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline / Prognostic_studies Idioma: En Revista: Front Physiol Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline / Prognostic_studies Idioma: En Revista: Front Physiol Año: 2017 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza