Unguiculins A-C: cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp.
Nat Prod Res
; 32(13): 1512-1517, 2018 Jul.
Article
en En
| MEDLINE
| ID: mdl-29067835
Two new acyclic bis-guanidine alkaloids, unguiculins B-C (2-3), were isolated from a French Polynesian sponge Monanchora n. sp. together with the known compound unguiculin A (1). Their structures were established by spectroscopic data interpretation and comparison with the literature. Unguiculins A-C displayed antiproliferative and cytotoxic efficacy against several human cancer cells with IC50 values in the micromolar range.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Poríferos
/
Alcaloides
/
Guanidinas
/
Antineoplásicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Prod Res
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Reino Unido