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Unguiculins A-C: cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp.
El-Demerdash, Amr; Moriou, Céline; Martin, Marie-Thérèse; Petek, Sylvain; Debitus, Cécile; Al-Mourabit, Ali.
Afiliación
  • El-Demerdash A; a Institut de Chimie des Substances Naturelles, CNRS UPR 2301 , University of Paris-Sud, Université Paris-Saclay , Gif-sur-Yvette , France.
  • Moriou C; b Faculty of Science, Organic Chemistry Division, Chemistry Department , Mansoura University , Mansoura , Egypt.
  • Martin MT; a Institut de Chimie des Substances Naturelles, CNRS UPR 2301 , University of Paris-Sud, Université Paris-Saclay , Gif-sur-Yvette , France.
  • Petek S; a Institut de Chimie des Substances Naturelles, CNRS UPR 2301 , University of Paris-Sud, Université Paris-Saclay , Gif-sur-Yvette , France.
  • Debitus C; c EIO, IRD, IFREMER, ILM, University of Polynésie française , French Polynesia , France.
  • Al-Mourabit A; d LEMAR, IRD, IFREMER, CNRS, University of Bretagne Occidentale , Plouzané , France.
Nat Prod Res ; 32(13): 1512-1517, 2018 Jul.
Article en En | MEDLINE | ID: mdl-29067835
Two new acyclic bis-guanidine alkaloids, unguiculins B-C (2-3), were isolated from a French Polynesian sponge Monanchora n. sp. together with the known compound unguiculin A (1). Their structures were established by spectroscopic data interpretation and comparison with the literature. Unguiculins A-C displayed antiproliferative and cytotoxic efficacy against several human cancer cells with IC50 values in the micromolar range.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poríferos / Alcaloides / Guanidinas / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Nat Prod Res Año: 2018 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poríferos / Alcaloides / Guanidinas / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Nat Prod Res Año: 2018 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido