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Isolation and structural identification of a novel minoxidil analogue in an illegal dietary supplement: triaminodil.
Lee, Ji Hyun; Park, Han Na; Park, Hyoung Joon; Kim, Nam Sook; Park, Sung-Kwan; Lee, Jongkook; Baek, Sun Young.
Afiliación
  • Lee JH; a Division of Advanced Analysis, Toxicological Evaluation and Research Department , National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety , Cheongju-si , Chungcheongbuk-do , Republic of Korea.
  • Park HN; a Division of Advanced Analysis, Toxicological Evaluation and Research Department , National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety , Cheongju-si , Chungcheongbuk-do , Republic of Korea.
  • Park HJ; a Division of Advanced Analysis, Toxicological Evaluation and Research Department , National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety , Cheongju-si , Chungcheongbuk-do , Republic of Korea.
  • Kim NS; a Division of Advanced Analysis, Toxicological Evaluation and Research Department , National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety , Cheongju-si , Chungcheongbuk-do , Republic of Korea.
  • Park SK; a Division of Advanced Analysis, Toxicological Evaluation and Research Department , National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety , Cheongju-si , Chungcheongbuk-do , Republic of Korea.
  • Lee J; b College of Pharmacy , Kangwon National University , Chuncheon , Gangwon-do , Republic of Korea.
  • Baek SY; a Division of Advanced Analysis, Toxicological Evaluation and Research Department , National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety , Cheongju-si , Chungcheongbuk-do , Republic of Korea.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess ; 35(1): 2-9, 2018 Jan.
Article en En | MEDLINE | ID: mdl-29067865
ABSTRACT
A new minoxidil analogue was detected in an illegal dietary supplement advertised as a hair-growth treatment. The analogue was identified using ultra-performance liquid chromatography (UPLC), high-resolution mass spectrometry (LC-HR-MS) and nuclear magnetic resonance (NMR) spectroscopy. The compound was structurally elucidated as a minoxidil analogue in which the piperidinyl group of minoxidil was replaced with a pyrrolidinyl group corresponding to a molecular formula of C8H13N5O. The new analogue has been named triaminodil. As this is the first report of the compound, there are no chemical, toxicology or pharmacological data available.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminación de Medicamentos / Suplementos Dietéticos / Minoxidil Tipo de estudio: Diagnostic_studies Idioma: En Revista: Food Addit Contam Part A Chem Anal Control Expo Risk Assess Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2018 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminación de Medicamentos / Suplementos Dietéticos / Minoxidil Tipo de estudio: Diagnostic_studies Idioma: En Revista: Food Addit Contam Part A Chem Anal Control Expo Risk Assess Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2018 Tipo del documento: Article