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From receptor binding kinetics to signal transduction; a missing link in predicting in vivo drug-action.
Nederpelt, Indira; Kuzikov, Maria; de Witte, Wilbert E A; Schnider, Patrick; Tuijt, Bruno; Gul, Sheraz; IJzerman, Adriaan P; de Lange, Elizabeth C M; Heitman, Laura H.
Afiliación
  • Nederpelt I; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.
  • Kuzikov M; Fraunhofer IME Screening Port, Schnackenburgallee 114, D-22525, Hamburg, Germany.
  • de Witte WEA; Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.
  • Schnider P; Roche Pharmaceutical Research and Early Development, Small Molecule Research, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070, Basel, Switzerland.
  • Tuijt B; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.
  • Gul S; Fraunhofer IME Screening Port, Schnackenburgallee 114, D-22525, Hamburg, Germany.
  • IJzerman AP; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.
  • de Lange ECM; Division of Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.
  • Heitman LH; Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands. l.h.heitman@lacdr.leidenuniv.nl.
Sci Rep ; 7(1): 14169, 2017 10 26.
Article en En | MEDLINE | ID: mdl-29075004
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sustancia P / Receptores de Neuroquinina-1 / Antagonistas del Receptor de Neuroquinina-1 / Aprepitant Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sustancia P / Receptores de Neuroquinina-1 / Antagonistas del Receptor de Neuroquinina-1 / Aprepitant Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos