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A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation.
Shi, Xiaofeng; Ba, Rong; You, Haiyan; Jiang, Qian; Huang, Jiansong; Mao, Jianhua; Han, Lanxiu; Zhang, Shuo; Zhuang, Qin; Yu, Xianqiu; Wang, Lixia; Wang, Yun; Li, Dongya; Zhu, Wei; Zhang, Yong; Zhu, Yan; Xi, Xiaodong.
Afiliación
  • Shi X; Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
  • Ba R; The Center of Thrombosis, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
  • You H; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Collaborative Innovation Center of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Jiang Q; Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
  • Huang J; Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
  • Mao J; Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
  • Han L; Institute of Hematology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
  • Zhang S; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Collaborative Innovation Center of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Zhuang Q; Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
  • Yu X; Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
  • Wang L; Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
  • Wang Y; Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
  • Li D; Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
  • Zhu W; Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
  • Zhang Y; Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212001, China.
  • Zhu Y; School of Medicine, Jiangsu University, Zhenjiang, 212013, China.
  • Xi X; Blood Cell Development and Function Program Fox Chase Cancer Center, 333 Cottman Avenue, Room 364, Philadelphia, PA, 19111-2497, USA.
Front Med ; 12(3): 324-329, 2018 Jun.
Article en En | MEDLINE | ID: mdl-29075958
ABSTRACT
Splenic lymphoma with villous lymphocytes (SLVL) or splenic marginal zone lymphoma with circulating villous lymphocytes is rare, and prolymphocytic transformation of SLVL is rarer. At present, only one case of SLVL with t(8;14)(q24;q32) translocation has been reported. In this study, we report a case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) chromosome translocation that we inclined to SLVL with a prolymphocytic transformation. A 73-year-old female showed marked hepatosplenomegaly and high lymphocytosis (lymphocytes > 200 × 109/L). The abnormal lymphocytes had short coarse villi and round nuclei with prominent nucleoli. The immunophenotypes showed CD19+, CD20+, HLA-DR+, CD22+, CD5+, Kappa+, CD25dim, CD71dim, Lambda-, CD7-, CD10-, CD23-, CD34-, CD33-, CD13-, CD14-, CD117-, CD64-, CD103-, and CD11c-. The karyotype showed complex abnormality 46XX,+ 3,-10, t(8;14)(q24; q32)[11]/46XX[9]. The cytoplasmic projection, immunological characteristics, and trisomy 3 chromosome abnormality supported the diagnosis of SLVL. However, the presence of prominent nucleoli and high lymphocytosis suggested prolymphocytic transformation, probably as a result of t(8,14) chromosome translocation. In this report, we described an unusual case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation, which could provide help in the diagnosis and differential diagnosis of B-lymphocytic proliferative diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Translocación Genética / Linfocitos B / Trastornos Linfoproliferativos Límite: Aged / Female / Humans Idioma: En Revista: Front Med Año: 2018 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Translocación Genética / Linfocitos B / Trastornos Linfoproliferativos Límite: Aged / Female / Humans Idioma: En Revista: Front Med Año: 2018 Tipo del documento: Article País de afiliación: China