Prosaccade and Antisaccade Paradigms in Persons with Alzheimer's Disease: A Meta-Analytic Review.
Neuropsychol Rev
; 28(1): 16-31, 2018 03.
Article
en En
| MEDLINE
| ID: mdl-29079970
ABSTRACT
Persons with Mild Cognitive Impairment (MCI) are at high Alzheimer's Disease (AD) risk but the development of sensitive measures to assess subtle cognitive decline in this population poses a major challenge for clinicians and researchers. Eye movement monitoring is a non-invasive, sensitive way to assess subtle cognitive processes in clinical populations. We conducted a critical review and a meta-analysis of the literature on pro and antisaccade paradigm in AD/MCI. The meta-analysis included 20 studies, all of which used the prosaccade paradigm and 13 of which studied the antisaccade paradigm as well. Our meta-analysis showed that AD but not MCI patients showed longer prosaccade latencies when compared to controls. While antisaccade latencies did not differentiate between patients from controls, antisaccade error rate were significantly increased among patients in comparison to controls in over 87% of the studies. These findings highlight antisaccade error rate as a reliable tool to distinguish inhibition abilities between AD/MCI and healthy older persons.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Movimientos Sacádicos
/
Enfermedad de Alzheimer
/
Pruebas Neuropsicológicas
Tipo de estudio:
Diagnostic_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Neuropsychol Rev
Asunto de la revista:
NEUROLOGIA
/
PSICOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Israel