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Results and evaluation of a first-in-human study of RG7342, an mGlu5 positive allosteric modulator, utilizing Bayesian adaptive methods.
Sturm, Stefan; Delporte, Marie-Laure; Hadi, Salah; Schobel, Scott; Lindemann, Lothar; Weikert, Robert; Jaeschke, Georg; Derks, Michael; Palermo, Giuseppe.
Afiliación
  • Sturm S; Roche Innovation Center Basel, Roche Pharmaceutical Research and Early Development, Grenzacherstrasse 124, Basel, Switzerland.
  • Delporte ML; Roche Innovation Center Basel, Roche Pharmaceutical Research and Early Development, Grenzacherstrasse 124, Basel, Switzerland.
  • Hadi S; PRA Health Sciences (PRA) - Early Development Services, Van Swietenlaan 6 Clinical Site, Groningen, the Netherlands.
  • Schobel S; Roche Innovation Center Basel, Roche Pharmaceutical Research and Early Development, Grenzacherstrasse 124, Basel, Switzerland.
  • Lindemann L; Roche Innovation Center Basel, Roche Pharmaceutical Research and Early Development, Grenzacherstrasse 124, Basel, Switzerland.
  • Weikert R; Roche Innovation Center Basel, Roche Pharmaceutical Research and Early Development, Grenzacherstrasse 124, Basel, Switzerland.
  • Jaeschke G; Roche Innovation Center Basel, Roche Pharmaceutical Research and Early Development, Grenzacherstrasse 124, Basel, Switzerland.
  • Derks M; Roche Innovation Center Welwyn, Roche Pharmaceutical Research and Early Development, 6 Falcon Way, Welwyn Garden City, UK.
  • Palermo G; Roche Innovation Center Basel, Roche Pharmaceutical Research and Early Development, Grenzacherstrasse 124, Basel, Switzerland.
Br J Clin Pharmacol ; 84(3): 445-455, 2018 03.
Article en En | MEDLINE | ID: mdl-29096426
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interacciones Alimento-Droga / Regulación Alostérica / Receptor del Glutamato Metabotropico 5 Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Br J Clin Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interacciones Alimento-Droga / Regulación Alostérica / Receptor del Glutamato Metabotropico 5 Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Br J Clin Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido