Preparation of electrospun core-sheath yarn with enhanced bioproperties for biomedical materials.
Biotechnol Lett
; 40(2): 279-284, 2018 Feb.
Article
en En
| MEDLINE
| ID: mdl-29119355
ABSTRACT
OBJECTIVES:
To create a multifunctional medical material that combines the advantages of both nanofibers and macroyarns.RESULTS:
A novel electrospinning-based approach was developed for creating polycaprolactone (PCL) nanofiber covered yarns (PCL-NCYs) in which polyglycolic acid multi-strand filaments (PGA-MFs) were used as the core. BALB/3T3 (mouse embryonic fibroblast cell line) cells were cultured on the PCL-NCYs substrate and cell morphology and proliferation were determined by methylthiazol tetrazolium (MTT) assay. Compared with PGA-MFs, PCL-NCYs had a higher porosity and tensile strength of 88 ± 8% and 348 ± 16 MPa and in particular, the porosity was four times higher. BALB/3T3 cells attached more easily onto the nanofiber structure and proliferated along the direction of nanofibers, indicating that PCL-NCYs can achieve better cell differentiation and proliferation.CONCLUSIONS:
PCL-NCYs can be created by combining electrospinning covering and textile twisting, and have better mechanical property and higher porosity, and can be used as a novel scaffold in tissue engineering.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Materiales Biocompatibles
/
Técnicas Electroquímicas
Límite:
Animals
Idioma:
En
Revista:
Biotechnol Lett
Año:
2018
Tipo del documento:
Article
País de afiliación:
China