The role of regulatory T cells in the regulation of upper airway inflammation.
Am J Rhinol Allergy
; 31(6): 345-351, 2017 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-29122078
ABSTRACT
Allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP) are inflammatory diseases of the upper airway, with a similar immunologic profile, characterized by aberrant and persistent type 2 inflammation. One cell population that has been identified as altered in both disease types is regulatory T cell (Treg). Tregs have the capacity to modulate T-effector function and suppress inflammatory cytokine production in a broad range of cell types. Given the ability of Tregs to control inflammation, the role of Tregs in respiratory diseases has attracted much attention. As discussed in this article, alterations in the Treg numbers and function, or both, have been identified in AR and CRSwNP, although much of the data is conflicting. Here, we explored what is known and, in many cases, unknown about the mechanisms by which Tregs differentiate and function, and how these functions can be controlled in the mucosal microenvironment. By gaining a greater understanding of these processes, it may be possible to harness the natural immunosuppressive activity of Tregs to ameliorate the chronic inflammation associated with AR and CRSwNP.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sinusitis
/
Rinitis
/
Pólipos Nasales
/
Linfocitos T Reguladores
/
Rinitis Alérgica
Límite:
Humans
Idioma:
En
Revista:
Am J Rhinol Allergy
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
OTORRINOLARINGOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos