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Risks of Infection and Mortality Among Patients Colonized With Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae: Validation of Scores and Proposal for Management.
Cano, Angela; Gutiérrez-Gutiérrez, Belén; Machuca, Isabel; Gracia-Ahufinger, Irene; Pérez-Nadales, Elena; Causse, Manuel; Castón, Juan José; Guzman-Puche, Julia; Torre-Giménez, Julian; Kindelán, Lara; Martínez-Martinez, Luis; Rodriguez-Baño, Jesús; Torre-Cisneros, Julian.
Afiliación
  • Cano A; Infectious Diseases Unit, Hospital Universitario Reina Sofía-Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC)-Universidad de Cordoba, Spain.
  • Gutiérrez-Gutiérrez B; Infectious Diseases Unit, Hospital Universitario Virgen Macarena-Instituto de Biomedicina de Sevilla (IBiS), Spain.
  • Machuca I; Department of Medicine, Universidad de Sevilla, Spain.
  • Gracia-Ahufinger I; Infectious Diseases Unit, Hospital Universitario Reina Sofía-Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC)-Universidad de Cordoba, Spain.
  • Pérez-Nadales E; Microbiology Unit, Hospital Universitario Reina Sofía-IMIBIC, Universidad de Cordoba, Spain.
  • Causse M; Maimónides Biomedical Research Institute of Córdoba (IMIBIC)-Reina Sofia University Hospital, University of Córdoba, Spain.
  • Castón JJ; Microbiology Unit, Hospital Universitario Reina Sofía-IMIBIC, Universidad de Cordoba, Spain.
  • Guzman-Puche J; Infectious Diseases Unit, Hospital Universitario Reina Sofía-Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC)-Universidad de Cordoba, Spain.
  • Torre-Giménez J; Microbiology Unit, Hospital Universitario Reina Sofía-IMIBIC, Universidad de Cordoba, Spain.
  • Kindelán L; Infectious Diseases Unit, Hospital Universitario Reina Sofía-Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC)-Universidad de Cordoba, Spain.
  • Martínez-Martinez L; Infectious Diseases Unit, Hospital Universitario Reina Sofía-Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC)-Universidad de Cordoba, Spain.
  • Rodriguez-Baño J; Microbiology Unit, Hospital Universitario Reina Sofía-IMIBIC, Universidad de Cordoba, Spain.
  • Torre-Cisneros J; Infectious Diseases Unit, Hospital Universitario Virgen Macarena-Instituto de Biomedicina de Sevilla (IBiS), Spain.
Clin Infect Dis ; 66(8): 1204-1210, 2018 04 03.
Article en En | MEDLINE | ID: mdl-29126110
ABSTRACT

Background:

The management and indication of empiric treatment in Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp)-colonized patients should be improved.

Methods:

A prospective cohort of 94 patients colonized by KPC-Kp was followed for 90 days to validate (i) the Giannella risk score (GRS) to predict the development of any type of KPC-Kp infection and (ii) the INCREMENT-CPE score (ICS) to predict 30-day mortality in patients with infection. Both scores were combined to recommend appropriate empiric treatment. The predictive ability of the scores was measured by calculating the area under the receiver operating characteristic (AUROC) curve.

Results:

The GRS showed an AUROC curve for infection due to KPC-Kp of 0.92 (95% confidence interval [CI], .87-.98). The optimal cutoff point was fixed at <7 and ≥7 (92.9% sensitivity, 84.8% specificity); infection developed in 6.3% patients in the 0-6 GRS group and in 84.8% patient in the ≥7 GRS group. According to the ICS, the severity of the infection was also significantly higher in the ≥7 GRS group. The ICS showed an AUROC of 0.78 (95% CI, .65-.91) for 30-day all-cause mortality among patients with infection. A classification and regression tree analysis confirmed the GRS cutoff point at 7, and selected ≥12 points to predict a KPC-Kp infection with a high ICS.

Conclusions:

Our results validate the GRS and ICS for indicating empiric therapy in KPC-Kp-colonized patients.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Beta-Lactamasas / Infecciones por Klebsiella / Klebsiella pneumoniae Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Beta-Lactamasas / Infecciones por Klebsiella / Klebsiella pneumoniae Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA