Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer.
Org Lett
; 19(24): 6490-6493, 2017 12 15.
Article
en En
| MEDLINE
| ID: mdl-29172548
ABSTRACT
An optimized large scale and highly reproducible route to orthogonally protected γ-thiolysine is reported. Its utility in the synthesis of bifunctional ubiquitin monomers is demonstrated. These ubiquitin synthons are employed in polymerization reactions giving access to synthetic poly-ubiquitin chains of defined linkage.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Países Bajos