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Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer.
van der Heden van Noort, Gerbrand J; Kooij, Raymond; Elliott, Paul R; Komander, David; Ovaa, Huib.
Afiliación
  • van der Heden van Noort GJ; Department of Chemical Immunology, Leiden University Medical Centre , 2333 ZC Leiden, The Netherlands.
  • Kooij R; Department of Chemical Immunology, Leiden University Medical Centre , 2333 ZC Leiden, The Netherlands.
  • Elliott PR; Medical Research Council Laboratory of Molecular Biology , Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom.
  • Komander D; Medical Research Council Laboratory of Molecular Biology , Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, United Kingdom.
  • Ovaa H; Department of Chemical Immunology, Leiden University Medical Centre , 2333 ZC Leiden, The Netherlands.
Org Lett ; 19(24): 6490-6493, 2017 12 15.
Article en En | MEDLINE | ID: mdl-29172548
ABSTRACT
An optimized large scale and highly reproducible route to orthogonally protected γ-thiolysine is reported. Its utility in the synthesis of bifunctional ubiquitin monomers is demonstrated. These ubiquitin synthons are employed in polymerization reactions giving access to synthetic poly-ubiquitin chains of defined linkage.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Países Bajos