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Automated lipid-rich plaque detection with short wavelength infra-red OCT system.
Shimokado, Aiko; Kubo, Takashi; Nishiguchi, Tsuyoshi; Katayama, Yosuke; Taruya, Akira; Ohta, Shingo; Kashiwagi, Manabu; Shimamura, Kunihiro; Kuroi, Akio; Kameyama, Takeyoshi; Shiono, Yasutsugu; Yamano, Takashi; Matsuo, Yoshiki; Kitabata, Hironori; Ino, Yasushi; Hozumi, Takeshi; Tanaka, Atsushi; Akasaka, Takashi.
Afiliación
  • Shimokado A; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Kubo T; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Nishiguchi T; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Katayama Y; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Taruya A; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Ohta S; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Kashiwagi M; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Shimamura K; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Kuroi A; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Kameyama T; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Shiono Y; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Yamano T; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Matsuo Y; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Kitabata H; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Ino Y; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Hozumi T; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Tanaka A; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
  • Akasaka T; Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
Eur Heart J Cardiovasc Imaging ; 19(10): 1174-1178, 2018 10 01.
Article en En | MEDLINE | ID: mdl-29186546
Aims: Vulnerable coronary plaque is characterized by a large lipid core. Although commercially-available optical coherence tomography (OCT) systems use near-infrared light at 1300 nm wavelength, lipid shows characteristic absorption at 1700 nm. Therefore, we developed a novel, short wavelength infra-red, spectroscopic, spectral-domain OCT. The aim of the present study is to evaluate the accuracy of short wavelength (1700 nm) infra-red optical coherence tomography (SWIR-OCT) for identification of lipid tissue within coronary plaques. Methods and results: Twenty-three coronary arteries from 10 cadavers were imaged at physiological pressure with 2.7 Fr SWIR-OCT catheter. When a blood-free image was observed, the SWIR-OCT imaging core was withdrawn at a rate of 20 mm/s using an automatic pullback device. SWIR-OCT images were acquired at 94 frames/s and digitally archived. SWIR-OCT generated grey-scale cross sectional images and colour tissue maps of all of the plaque by using a lipid analysis algorithm. After SWIR-OCT imaging, the arteries were pressure-fixed, sliced by cryostat and stained with Oil Red O, and then corresponding histology was collected in matched images. Regions of interest, selected from histology, were 117 lipidic and 34 fibrotic/calcified regions. SWIR-OCT showed high sensitivity (89%) and specificity (92%) for identifying lipid tissue within coronary plaques. The positive predictive value and negative predictive value were 97% and 74%, respectively. Conclusion: SWIR-OCT accurately identified lipid tissue in coronary autopsy specimens. This new technique may hold promise for identifying histopathological features of coronary plaque at risk for rupture.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Vasos Coronarios / Tomografía de Coherencia Óptica / Placa Aterosclerótica / Rayos Infrarrojos Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Eur Heart J Cardiovasc Imaging Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Vasos Coronarios / Tomografía de Coherencia Óptica / Placa Aterosclerótica / Rayos Infrarrojos Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Eur Heart J Cardiovasc Imaging Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido