Growth of B Cell Receptor Microclusters Is Regulated by PIP<sub>2</sub> and PIP<sub>3</sub> Equilibrium and Dock2 Recruitment and Activation.

Wang, Jing; Xu, Liling; Shaheen, Samina; Liu, Sichen; Zheng, Wenjie; Sun, Xiaolin; Li, Zhanguo; Liu, Wanli

Growth of B Cell Receptor Microclusters Is Regulated by PIP₂ and PIP₃ Equilibrium and Dock2 Recruitment and Activation.

Wang, Jing; Xu, Liling; Shaheen, Samina; Liu, Sichen; Zheng, Wenjie; Sun, Xiaolin; Li, Zhanguo; Liu, Wanli.

Afiliación

Wang J; MOE Key Laboratory of Protein Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Institute for Immunology, Tsinghua University, Beijing 100084, China.
Xu L; MOE Key Laboratory of Protein Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Institute for Immunology, Tsinghua University, Beijing 100084, China.
Shaheen S; MOE Key Laboratory of Protein Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Institute for Immunology, Tsinghua University, Beijing 100084, China.
Liu S; MOE Key Laboratory of Protein Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Institute for Immunology, Tsinghua University, Beijing 100084, China.
Zheng W; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Sun X; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing 100044, China.
Li Z; Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing 100044, China.
Liu W; MOE Key Laboratory of Protein Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Institute for Immunology, Tsinghua University, Beijing 100084, China. Electronic address: liulab@tsinghua.edu.cn.

Cell Rep ; 21(9): 2541-2557, 2017 Nov 28.

Article en En | MEDLINE | ID: mdl-29186690

Asunto(s)

Fosfatidilinositol 3-Quinasas/metabolismo; Citoesqueleto de Actina/genética; Citoesqueleto de Actina/metabolismo; Actinas/metabolismo; Adulto; Linfocitos B/inmunología; Linfocitos B/metabolismo; Femenino; Proteínas Activadoras de GTPasa; Factores de Intercambio de Guanina Nucleótido/genética; Factores de Intercambio de Guanina Nucleótido/metabolismo; Humanos; Sinapsis Inmunológicas/genética; Sinapsis Inmunológicas/metabolismo; Activación de Linfocitos/genética; Activación de Linfocitos/fisiología; Masculino; Persona de Mediana Edad; Fosfohidrolasa PTEN/genética; Fosfohidrolasa PTEN/metabolismo; Fosfatidilinositol 3-Quinasas/genética; Receptores de Antígenos de Linfocitos B/genética; Receptores de Antígenos de Linfocitos B/metabolismo; Transducción de Señal/genética; Transducción de Señal/fisiología; Adulto Joven

Palabras clave

BCR microclusters; Dock2; PI3K; PIP(2); PIP(3); PTEN; growth of BCR microclusters

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatidilinositol 3-Quinasas Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Rep Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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