Natural Bioactive New Withanolides.

Xu, Qian-Qian; Wang, Kui-Wu

Xu, Qian-Qian; Wang, Kui-Wu.

Afiliación

Xu QQ; Department of Applied Chemistry, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China.
Wang KW; Department of Applied Chemistry, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China.

Mini Rev Med Chem ; 20(12): 1101-1117, 2020.

Article en En | MEDLINE | ID: mdl-29189150

RESUMEN

Withanolides are a group of highly oxygenated steroids derived from a C28 ergostane skeleton, and have attracted significant scientific interest due to their complex structural features and multiple bioactivities. More than 170 new natural withanolides were isolated and identified in the last 5 years. This review provides a comprehensive summary of the structural, biological and pharmacological activities of these new compounds.

Asunto(s)

Antiinfecciosos/química; Witanólidos/química; Animales; Antozoos/química; Antozoos/metabolismo; Antiinfecciosos/farmacología; Citocinas/metabolismo; Datura/química; Datura/metabolismo; Ergosterol/análogos & derivados; Ergosterol/química; Macrófagos/citología; Macrófagos/efectos de los fármacos; Macrófagos/metabolismo; Conformación Molecular; Withania/química; Withania/metabolismo

Palabras clave

Withanolide; anti-inflammatory; antistress; biological activities; oxygenated steroids; structure

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Witanólidos / Antiinfecciosos Límite: Animals Idioma: En Revista: Mini Rev Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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