Effects of adding Rheum officinale to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on renal function in patients with chronic renal failure: A meta-analysis of randomized controlled trialsâ©.
Clin Nephrol
; 89(6): 445-454, 2018 Jun.
Article
en En
| MEDLINE
| ID: mdl-29208203
ABSTRACT
OBJECTIVE:
METHODS:
The MEDLINE, EMBASE, Cochrane Library, SinoMed, Chinese National Knowledge Infrastructure, Wanfang, and VIP databases were searched to identify studies published before September 2016 that investigated the effects of ACEI/ARB plus the Chinese patented medicine Rheum (CPM-Rheum) compared to ACEI/ARB alone in lowering serum creatinine (SCr) and blood urea nitrogen (BUN) levels in chronic renal failure patients. Review Manager 5.3 was used to perform the meta-analysis. Fixed- and random-effects models were used to analyze the data.RESULTS:
The meta-analysis included nine clinical trials. Comparisons of patients before and after treatment with ACEI/ARB plus CPM-Rheum or ACEI/ARB alone revealed that ACEI/ARB plus CPM-Rheum resulted in significantly greater reductions in SCr (short-term weighted mean difference (WMD) 17.26, 95% confidence interval (CI) 7.28 - 27.24; long-term WMD 63.71, 95% CI 51.01 - 76.41) and BUN (short-term WMD 1.70, 95% CI 1.27 - 2.12; long-term WMD 3.98, 95% CI 3.14 - 4.82) than ACEI/ARB alone.CONCLUSION:
In patients with chronic renal failure, the addition of CPM-Rheum to ACEI/ARB significantly lowered both SCr and BUN, particularly after long-term administration. Thus, the combination of ACEI/ARB and CPM-Rheum may improve the treatment of patients with impaired renal function.â©.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Rheum
/
Inhibidores de la Enzima Convertidora de Angiotensina
/
Extractos Vegetales
/
Antagonistas de Receptores de Angiotensina
/
Fallo Renal Crónico
Tipo de estudio:
Clinical_trials
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Clin Nephrol
Año:
2018
Tipo del documento:
Article