Chemical constituents of Oldenlandia pinifolia and their antiproliferative activities.
Nat Prod Res
; 33(6): 796-802, 2019 Mar.
Article
en En
| MEDLINE
| ID: mdl-29210295
ABSTRACT
This study describes the chemical constituents of Oldenlandia pinifolia (Wall. Ex G. Don) Kuntze (synonym Hedyotis pinifolia Wall. Ex G. Don) and discusses their anti-proliferative activities. Thirteen compounds were isolated from the n-hexane, ethyl acetate and n-butanol extracts of whole plants O. pinifolia by chromatography method. Their structures were elucidated using MS and NMR analysis and compared with reported data. They are three anthraquinones, a carotenoid, two triterpenes, four iridoid glycosides and three flavonoid glycosides. Among them, 2-methyl-1,4,6-trihydroxy-anthraquinone is a new one, and three compounds were found for the first time in this genus. MTT assay resulted that the n-butanol extract and four isolated compounds inhibited the proliferation of chronic myelogenous leukaemia cells. The results from Hoechst 33343 staining and caspase 3-inducing exhibited that those four tested compounds induced apoptosis and activated caspase 3 (p < 0.05). One of them, isorhamnetin-3-O-ß-rutinoside showed the most activity with IC50 value of 394.68 ± 25.12 µM.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Flavonoides
/
Extractos Vegetales
/
Oldenlandia
/
Disacáridos
/
Antineoplásicos Fitogénicos
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Nat Prod Res
Año:
2019
Tipo del documento:
Article
País de afiliación:
Vietnam