Antitumor action of 3-bromopyruvate implicates reorganized tumor growth regulatory components of tumor milieu, cell cycle arrest and induction of mitochondria-dependent tumor cell death.

Yadav, Saveg; Kujur, Praveen Kumar; Pandey, Shrish Kumar; Goel, Yugal; Maurya, Babu Nandan; Verma, Ashish; Kumar, Ajay; Singh, Rana Pratap; Singh, Sukh Mahendra

Yadav, Saveg; Kujur, Praveen Kumar; Pandey, Shrish Kumar; Goel, Yugal; Maurya, Babu Nandan; Verma, Ashish; Kumar, Ajay; Singh, Rana Pratap; Singh, Sukh Mahendra.

Afiliación

Yadav S; School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
Kujur PK; Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Pandey SK; School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
Goel Y; School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
Maurya BN; Department of Radiodiagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Verma A; Department of Radiodiagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Kumar A; Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
Singh RP; Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Singh SM; School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi 221005, India. Electronic address: sukhmahendrasingh@yahoo.com.

Toxicol Appl Pharmacol ; 339: 52-64, 2018 01 15.

Article en En | MEDLINE | ID: mdl-29221953

Asunto(s)

Antineoplásicos/farmacología; Puntos de Control del Ciclo Celular/efectos de los fármacos; Mitocondrias/efectos de los fármacos; Piruvatos/farmacología; Carga Tumoral/efectos de los fármacos; Microambiente Tumoral/efectos de los fármacos; Animales; Puntos de Control del Ciclo Celular/fisiología; Muerte Celular/efectos de los fármacos; Muerte Celular/fisiología; Inhibidores Enzimáticos/farmacología; Ratones; Ratones Endogámicos BALB C; Mitocondrias/metabolismo; Mitocondrias/patología; Carga Tumoral/fisiología; Microambiente Tumoral/fisiología

Palabras clave

3-Bromopyruvate; Tumor metabolism; Tumor milieu; Tumor progression

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piruvatos / Carga Tumoral / Microambiente Tumoral / Puntos de Control del Ciclo Celular / Mitocondrias / Antineoplásicos Límite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: India

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