The use of the Petri net method in the simulation modeling of mitochondrial swelling.
Ukr Biochem J
; 88(4): 66-74, 2016.
Article
en En
| MEDLINE
| ID: mdl-29235789
ABSTRACT
Using photon correlation spectroscopy, which allows investigating changes in the hydrodynamic diameter of the particles in suspension, it was shown that ultrahigh concentrations of Ca2+ (over 10 mM) induce swelling of isolated mitochondria. An increase in hydrodynamic diameter was caused by an increase of non-specific mitochondrial membrane permeability to Ca ions, matrix Ca2+ overload, activation of ATP- and Ca2+-sensitive K+-channels, as well as activation of cyclosporin-sensitive permeability transition pore. To formalize the experimental data and to assess conformity of experimental results with theoretical predictions we developed a simulation model using the hybrid functional Petri net method.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Calcio
/
Ciclosporina
/
Mitocondrias
/
Dilatación Mitocondrial
/
Modelos Biológicos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Ukr Biochem J
Año:
2016
Tipo del documento:
Article