Isolation of sinapic acid from broccoli using molecularly imprinted polymers.
J Sep Sci
; 41(5): 1164-1172, 2018 Mar.
Article
en En
| MEDLINE
| ID: mdl-29239525
ABSTRACT
A molecularly imprinted polymer was synthesized for the purpose of sinapic acid isolation from Egyptian nutraceutical Botrytis italica, L. (broccoli) due to its prominent medicinal and wide pharmacological activities. A computational study was first developed to determine the optimal template to functional monomer molar ratio. Based on the computational results, five polymers were synthesized using a bulk polymerization method with sinapic acid as the template molecule. Evaluation of the synthesized polymers binding performance was carried out using batch rebinding assay, which revealed that the molecularly imprinted polymer of molar ratio (1420), template to functional monomer (4-vinyl pyridine) to crosslinker (ethylene glycol dimethacrylate) was of optimum performance, thus, this polymer was applied for sinapic acid isolation from closely related analogues. This represents a more practical approach to isolate sinapic acid from different natural extracts selectively.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polímeros
/
Teoría Cuántica
/
Brassica
/
Ácidos Cumáricos
/
Impresión Molecular
Idioma:
En
Revista:
J Sep Sci
Año:
2018
Tipo del documento:
Article
País de afiliación:
Egipto