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Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.
Schapansky, Jason; Khasnavis, Saurabh; DeAndrade, Mark P; Nardozzi, Jonathan D; Falkson, Samuel R; Boyd, Justin D; Sanderson, John B; Bartels, Tim; Melrose, Heather L; LaVoie, Matthew J.
Afiliación
  • Schapansky J; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States.
  • Khasnavis S; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States.
  • DeAndrade MP; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States.
  • Nardozzi JD; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States.
  • Falkson SR; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States.
  • Boyd JD; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States.
  • Sanderson JB; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States.
  • Bartels T; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States.
  • Melrose HL; Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, United States.
  • LaVoie MJ; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States. Electronic address: mlavoie@rics.bwh.harvard.edu.
Neurobiol Dis ; 111: 26-35, 2018 03.
Article en En | MEDLINE | ID: mdl-29246723
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alfa-Sinucleína / Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina / Lisosomas / Mutación / Neuronas Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alfa-Sinucleína / Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina / Lisosomas / Mutación / Neuronas Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos