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Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action.
Robinson, James I; Baxter, Euan W; Owen, Robin L; Thomsen, Maren; Tomlinson, Darren C; Waterhouse, Mark P; Win, Stephanie J; Nettleship, Joanne E; Tiede, Christian; Foster, Richard J; Owens, Raymond J; Fishwick, Colin W G; Harris, Sarah A; Goldman, Adrian; McPherson, Michael J; Morgan, Ann W.
Afiliación
  • Robinson JI; Leeds Institute of Rheumatic and Musculoskeletal Medicine, School of Medicine, University of Leeds, Leeds LS9 7TF, United Kingdom.
  • Baxter EW; National Institute of Health Research-Leeds Biomedical Research Centre, Chapel Allerton Hospital, Leeds LS7 4SA, United Kingdom.
  • Owen RL; Leeds Institute of Rheumatic and Musculoskeletal Medicine, School of Medicine, University of Leeds, Leeds LS9 7TF, United Kingdom.
  • Thomsen M; National Institute of Health Research-Leeds Biomedical Research Centre, Chapel Allerton Hospital, Leeds LS7 4SA, United Kingdom.
  • Tomlinson DC; Diamond Light Source, Didcot OX11 0DE, United Kingdom.
  • Waterhouse MP; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
  • Win SJ; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
  • Nettleship JE; BioScreening Technology Group, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
  • Tiede C; Leeds Institute of Rheumatic and Musculoskeletal Medicine, School of Medicine, University of Leeds, Leeds LS9 7TF, United Kingdom.
  • Foster RJ; National Institute of Health Research-Leeds Biomedical Research Centre, Chapel Allerton Hospital, Leeds LS7 4SA, United Kingdom.
  • Owens RJ; Leeds Institute of Rheumatic and Musculoskeletal Medicine, School of Medicine, University of Leeds, Leeds LS9 7TF, United Kingdom.
  • Fishwick CWG; National Institute of Health Research-Leeds Biomedical Research Centre, Chapel Allerton Hospital, Leeds LS7 4SA, United Kingdom.
  • Harris SA; Oxford Protein Production Facility-United Kingdom Research Complex at Harwell, Rutherford Appleton Laboratory, Oxford OX11 0FA, United Kingdom.
  • Goldman A; Division of Structural Biology, Wellcome Trust Centre for Genomic Medicine, Nuffield Department of Medicine, Oxford University, Oxford OX3 7BN, United Kingdom.
  • McPherson MJ; BioScreening Technology Group, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
  • Morgan AW; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom.
Proc Natl Acad Sci U S A ; 115(1): E72-E81, 2018 01 02.
Article en En | MEDLINE | ID: mdl-29247053
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina G / Receptores de IgG / Simulación de Dinámica Molecular / Complejo Antígeno-Anticuerpo Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina G / Receptores de IgG / Simulación de Dinámica Molecular / Complejo Antígeno-Anticuerpo Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido