Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions.

Kim, Jeongkyu; Sturgill, David; Sebastian, Robin; Khurana, Simran; Tran, Andy D; Edwards, Garrett B; Kruswick, Alex; Burkett, Sandra; Hosogane, Eri K; Hannon, William W; Weyemi, Urbain; Bonner, William M; Luger, Karolin; Oberdoerffer, Philipp

Kim, Jeongkyu; Sturgill, David; Sebastian, Robin; Khurana, Simran; Tran, Andy D; Edwards, Garrett B; Kruswick, Alex; Burkett, Sandra; Hosogane, Eri K; Hannon, William W; Weyemi, Urbain; Bonner, William M; Luger, Karolin; Oberdoerffer, Philipp.

Afiliación

Kim J; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Sturgill D; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Sebastian R; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Khurana S; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Tran AD; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Edwards GB; Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
Kruswick A; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Burkett S; Molecular Cytogenetics Core Facility, National Cancer Institute, NIH, Frederick, MD 21702, USA.
Hosogane EK; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Hannon WW; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Weyemi U; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Bonner WM; Developmental Therapeutics Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Luger K; Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
Oberdoerffer P; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: philipp.oberdoerffer@nih.gov.

Mol Cell ; 69(1): 36-47.e7, 2018 01 04.

Article en En | MEDLINE | ID: mdl-29249653

Asunto(s)

Carcinogénesis/genética; Cromatina/genética; Daño del ADN/genética; Reparación del ADN/genética; Replicación del ADN/genética; Histonas/genética; Recombinación Homóloga/genética; Proteína BRCA1/metabolismo; División Celular/genética; Células Cultivadas; Senescencia Celular/genética; Inestabilidad Genómica/fisiología; Humanos; Transducción de Señal/genética

Palabras clave

DNA repair; FACT; chromatin; macro-histone; macroH2A1.2; replication stress; senescence

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Cromatina / Histonas / Reparación del ADN / Replicación del ADN / Recombinación Homóloga / Carcinogénesis Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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