Your browser doesn't support javascript.
loading
ATP-degrading ENPP1 is required for survival (or persistence) of long-lived plasma cells.
Wang, Hongsheng; Gonzalez-Garcia, Ines; Traba, Javier; Jain, Shweta; Conteh, Solomon; Shin, Dong-Mi; Qi, Chenfeng; Gao, Yuanyuan; Sun, Jiafang; Kang, Sungyun; Abbasi, Sadia; Naghashfar, Zohreh; Yoon, Jeongheon; DuBois, Wendy; Kovalchuk, Alexander L; Sack, Michael N; Duffy, Patrick; Morse, Herbert C.
Afiliación
  • Wang H; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA. wanghongs@niaid.nih.gov.
  • Gonzalez-Garcia I; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
  • Traba J; Celgene Institute of Translational Research Europe, Parque Tecnológico Cartuja 93, c/Isaac Newton n.4, E-41092, Seville, Spain.
  • Jain S; Laboratory of Mitochondrial Biology and Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20814, USA.
  • Conteh S; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
  • Shin DM; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
  • Qi C; Department of Food and Nutrition, Seoul National University, Seoul, 151-742, Korea.
  • Gao Y; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
  • Sun J; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
  • Kang S; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
  • Abbasi S; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
  • Naghashfar Z; Department of Biology, Indiana University, Myers Hall 230, 915 E. 3rd St., Bloomington, IN, 47405, USA.
  • Yoon J; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
  • DuBois W; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
  • Kovalchuk AL; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
  • Sack MN; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.
  • Duffy P; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20814, USA.
  • Morse HC; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
Sci Rep ; 7(1): 17867, 2017 12 19.
Article en En | MEDLINE | ID: mdl-29259245
ABSTRACT
Survival of antibody-secreting plasma cells (PCs) is vital for sustained antibody production. However, it remains poorly understood how long-lived PCs (LLPCs) are generated and maintained. Here we report that ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is preferentially upregulated in bone marrow LLPCs compared with their splenic short-lived counterparts (SLPCs). We studied ENPP1-deficient mice (Enpp1 -/- ) to determine how the enzyme affects PC biology. Although Enpp1 -/- mice generated normal levels of germinal center B cells and plasmablasts in periphery, they produced significantly reduced numbers of LLPCs following immunization with T-dependent antigens or infection with plasmodium C. chabaudi. Bone marrow chimeric mice showed B cell intrinsic effect of ENPP1 selectively on generation of bone marrow as well as splenic LLPCs. Moreover, Enpp1 -/- PCs took up less glucose and had lower levels of glycolysis than those of wild-type controls. Thus, ENPP1 deficiency confers an energetic disadvantage to PCs for long-term survival and antibody production.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Plasmáticas / Pirofosfatasas / Adenosina Trifosfato / Hidrolasas Diéster Fosfóricas Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Plasmáticas / Pirofosfatasas / Adenosina Trifosfato / Hidrolasas Diéster Fosfóricas Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos