Your browser doesn't support javascript.
loading
Methylmercury Intoxication Promotes Metallothionein Response and Cell Damage in Salivary Glands of Rats.
Lima, Leidiane Alencar de Oliveira; Bittencourt, Leonardo Oliveira; Puty, Bruna; Fernandes, Rafael Monteiro; Nascimento, Priscila Cunha; Silva, Marcia Cristina Freitas; Alves-Junior, Sérgio Melo; Pinheiro, João de Jesus Viana; Lima, Rafael Rodrigues.
Afiliación
  • Lima LAO; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Street Augusto Correa N. 01, Guamá, Belém, Para, 66075-900, Brazil.
  • Bittencourt LO; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Street Augusto Correa N. 01, Guamá, Belém, Para, 66075-900, Brazil.
  • Puty B; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Street Augusto Correa N. 01, Guamá, Belém, Para, 66075-900, Brazil.
  • Fernandes RM; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Street Augusto Correa N. 01, Guamá, Belém, Para, 66075-900, Brazil.
  • Nascimento PC; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Street Augusto Correa N. 01, Guamá, Belém, Para, 66075-900, Brazil.
  • Silva MCF; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Street Augusto Correa N. 01, Guamá, Belém, Para, 66075-900, Brazil.
  • Alves-Junior SM; School of Dentistry, Federal University of Para, Belem, Para, Brazil.
  • Pinheiro JJV; School of Dentistry, Federal University of Para, Belem, Para, Brazil.
  • Lima RR; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Street Augusto Correa N. 01, Guamá, Belém, Para, 66075-900, Brazil. rafalima@ufpa.br.
Biol Trace Elem Res ; 185(1): 135-142, 2018 Sep.
Article en En | MEDLINE | ID: mdl-29332268
Environmental and occupational mercury exposure is considered a major public health issue. Despite being well known that MeHg exposure causes adverse effects in several physiologic functions, MeHg effects on salivary glands still not completely elucidated. Here, we investigated the cellular MeHg-induced damage in the three major salivary glands (parotid, submandibular, and sublingual) of adult rats after chronic, systemic and low doses of MeHg exposure. Rats were exposed by 0.04 mg/kg/day over 60 days. After that, animals were euthanized and all three glands were collected. We evaluated total Hg accumulation, metallothionein I/II (MT I/II), α-smooth muscle actin (α-SMA), and cytokeratin 18 (CK18) immune expression. Our results have showed that MeHg is able to disrupt gland tissue and to induce a protective mechanism by MT I/II expression. We also showed that cell MT production is not enough to protect gland tissue against cellular structural damage seen by reducing marking of cytoskeletal proteins as CK18 and α-SMA. Our data suggest that chronic MeHg exposure in low-daily doses is able to induce cellular damage in rat salivary glands.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándulas Salivales / Metalotioneína / Compuestos de Metilmercurio Límite: Animals Idioma: En Revista: Biol Trace Elem Res Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándulas Salivales / Metalotioneína / Compuestos de Metilmercurio Límite: Animals Idioma: En Revista: Biol Trace Elem Res Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos