To the Brain and Back: Migratory Paths of Dendritic Cells in Multiple Sclerosis.
J Neuropathol Exp Neurol
; 77(3): 178-192, 2018 03 01.
Article
en En
| MEDLINE
| ID: mdl-29342287
ABSTRACT
Migration of dendritic cells (DC) to the central nervous system (CNS) is a critical event in the pathogenesis of multiple sclerosis (MS). While up until now, research has mainly focused on the transmigration of DC through the blood-brain barrier, experimental evidence points out that also the choroid plexus and meningeal vessels represent important gateways to the CNS, especially in early disease stages. On the other hand, DC can exit the CNS to maintain immunological tolerance to patterns expressed in the CNS, a process that is perturbed in MS. Targeting trafficking of immune cells, including DC, to the CNS has demonstrated to be a successful strategy to treat MS. However, this approach is known to compromise protective immune surveillance of the brain. Unravelling the migratory paths of regulatory and pathogenic DC within the CNS may ultimately lead to the design of new therapeutic strategies able to selectively interfere with the recruitment of pathogenic DC to the CNS, while leaving host protective mechanisms intact.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Dendríticas
/
Encéfalo
/
Movimiento Celular
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Esclerosis Múltiple
Límite:
Humans
Idioma:
En
Revista:
J Neuropathol Exp Neurol
Año:
2018
Tipo del documento:
Article