O-GlcNAcylation: key regulator of glycolytic pathways.

Bacigalupa, Zachary A; Bhadiadra, Chaitali H; Reginato, Mauricio J

Bacigalupa, Zachary A; Bhadiadra, Chaitali H; Reginato, Mauricio J.

Afiliación

Bacigalupa ZA; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA, 19102, USA.
Bhadiadra CH; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA, 19102, USA.
Reginato MJ; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA, 19102, USA. Mauricio.Reginato@drexelmed.edu.

J Bioenerg Biomembr ; 50(3): 189-198, 2018 06.

Article en En | MEDLINE | ID: mdl-29344764

ABSTRACT

ABSTRACT

Elevated O-GlcNAcylation is emerging as a general characteristic of most cancers. Although O-GlcNAcylation can regulate many cell biological pathways, recent evidence suggests that it is a key regulator of metabolic pathways including glycolysis in cancer cells. This review summarizes our current understanding of how O-GlcNAcylation regulates glycolytic pathways and contributes to alterations in cancer cell metabolism.

Asunto(s)

Acetilglucosamina/metabolismo; Glucólisis; Redes y Vías Metabólicas; Sistema Nervioso/metabolismo; Animales; Glicosilación; Humanos

Palabras clave

Cancer; Glycolysis; Metabolism; O-GlcNAc transferase; O-GlcNAcylation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acetilglucosamina / Redes y Vías Metabólicas / Glucólisis / Sistema Nervioso Límite: Animals / Humans Idioma: En Revista: J Bioenerg Biomembr Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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